◆What is POC (Products of Conception) Testing?

Human cells typically contain a total of 46 chromosomes, contributed equally by the father and mother. Aneuploidy occurring before implantation can potentially lead to miscarriage or difficulty in sustaining pregnancy. POC testing examines the chromosomal makeup of fetal tissue following miscarriage, targeting individuals with a history of recurrent miscarriages or those undergoing assisted reproductive technology procedures.

It is estimated that 15-20% of pregnancies in humans end in miscarriage, with rates as high as 5-6 individuals out of 1 particularly among younger age groups. The primary cause is typically "sporadic" numerical chromosomal abnormalities, unrelated to illness or genetic conditions. However, in cases of recurrent miscarriage, there may be other underlying causes beyond sporadic errors.

POC (Products of Conception) testing is performed as a means to identify the causes of recurrent miscarriages. By surgically obtaining tissue from miscarried pregnancies and culturing it to examine the number and morphology of chromosomes, POC testing can reveal detailed insights into fetal chromosomal abnormalities and maternal factors. This information is crucial for determining future treatment strategies.

◆Advantages of POC Testing

◆Test Results and Treatment Progression

◆Points to Note

Due to the limited availability of fetal tissue, careful selection of chorionic villi is necessary, and attention must be paid to the difficulty of obtaining maternal blood and uterine contents. Early submission of specimens is desirable, and chorionic tissue should be stored without freezing. POC testing is not covered by insurance and involves a high cost for patients. If interpretation of the results is difficult, referral to a specialized facility capable of reproductive and perinatal genetic medical care is recommended. POC testing includes not only numerical chromosomal abnormalities but also mosaicisms, marker chromosomes, and structural abnormalities, requiring specialized knowledge in medical genetics.